Evodiamine is a bioactive alkaloid extract from a plant called Evodiae Fructus. This is a Chinese herb named Wu-Chu-Yu that Chinese herbalist have used for centuries as a weight loss supplement. No known human studies have been published to date. Based on studies done in laboratories using isolated cells and rodents, evodiamine can raise body temperature, influence the metabolism of certain drugs, and influence the secretion of catecholamines from the adrenal glands. Evodiamine stimulates the vanilloids to reduce the uptake of fat and increase the natural rate of burning fat. Recent scientific studies have backed up this traditional knowledge. Mammals fed a high-fat diet plus evodiamine actually lose, rather than gain weight. This herbal extract is a mild, yet remarkable stimulant that has shown positive energy and diuretic characteristics. Even more exciting is its unique ability to significantly elevate the production of body heat and increase resting core temperature. This thermogenic effect may lead to an increase in the calories and fat that are burned for energy. Evodiamine could be one of the biggest breakthroughs in thermogenesis to date.