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Natural Vitamin E Succinate

Number of views:
1000

Natural Vitamin E Succinate

Natural Vitamin E powder 30% Effect: (1)It is a kind of nutritional intensify additive, which can enhance the immunity, disease prevention of the livestocks. (2)Increasing breeding or laying rate of the livestocks and poultry, while keep the meat tasty and increase nutritional value. (3)It can effectively increase the nucleic acid metabolism, and promote protein synthesis, and increase the body functions and sexual function. (4)Phytosterols (animal growth additive) can combine with other growth hormone to formed molecule velar fat in the body, made of phytosterols ribosomal protein, and promote the rapid growth of animals. (5)It is a high-security antioxidants, the United States take it into the FDA GRAS, can replace chemical antioxidant such as ethoxy-quinoline, TBHQ and so on, can prevent the degeneration of the feeds.
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Alpha-tocopheryl succinate (alpha-TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas alpha-tocopherol (alpha-TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15: 403-415, 2001). Here we investigated the possible antineoplastic activities of alpha-TOH and alpha-TOS and further explored the potential of alpha-TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that alpha-TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, alpha-TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction of tumor cell apoptosis. alpha-TOS was nontoxic to normal cells and tissues, triggered apoptosis in p53(-/-) and p21(Waf1/Cip1(-/-)) cancer cells, and exerted a cooperative proapoptotic activity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) due to differences in proapoptotic signaling. Finally, alpha-TOS cooperated with tumor necrosis factor-related apoptosis-inducing ligand in suppression of tumor growth in vivo. Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential.

 
 
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